Canine model of pacing-induced heart failure

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August undefined, 2024

WebJan 20, 1998 · Pacing-induced heart failure is characterized by defects in nitric oxide generation, 14 and this alteration may increase the respiratory activity of mitochondria … WebJul 10, 2024 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling ...

Biatrial appendage hypertrophy but not ventricular hypertrophy…

WebCanine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University School of Medicine … WebFeb 18, 2014 · Some patients even develop severely depressed LV function within a short time frame, a condition that has been coined ‘dyssynchronopathy’ in a canine model of AV block that develops rapid heart failure. 10 Development of a dyssynchronopathy might also explain the well-known but ill-defined group of super-responders to CRT. 11 It should be ... shula\\u0027s hotel and golf club miami lakes fl

Global and regional wall motion abnormalities of pacing-induced heart ...

WebBackground Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure. WebMyocardial Akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (TNF-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes III and V and apoptosis initiation. shula\\u0027s gym schedule

Biatrial appendage hypertrophy but not ventricular hypertrophy…

Early recovery from heart failure: insights into the pathogenesis of ...

WebJun 1, 1999 · In the canine pacing model, we first reported the appearance of interstitial edema and disruption/disappearance of collagen fibers in the hearts of these animals as … WebApr 12, 2024 · Liu et al. used a rapid pacing model in vitro and a canine model of rapid pacing to establish the implication of miR-23a-3p in ferroptosis during AF. ... Yanni et al. used an animal model of heart failure that developed sinus bradycardia to demonstrate the function ... Lower levels of cardiac fibrosis are clinically associated with drug-induced ... shula\u0027s happy hour menuWebThe mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) … shula\\u0027s health club

"WebTachycardias can lead to ventricular contractile dysfunction, and rapid pacing is widely used to produce animal models of cardiomyopathy and atrial fibrillation . Abnormalities of cardiac Ca 2+ handling is one of the proposed mechanisms underlying the … " - Canine model of pacing-induced heart failure

Canine model of pacing-induced heart failure

Ca2+ clock malfunction in a canine model of pacing …

WebMay 10, 2016 · In pacing-induced canine models of heart failure, marked upregulation of adenosine A1 receptors occurs with increased sensitivity to adenosine induced SN dysfunction and AF. 67. Download figure; Download PowerPoint; Figure 4. Rhythm strip showing the effect of adenosine on the sinus node and atrium. Intravenous adenosine … WebFeb 1, 2004 · Heart failure was induced in 15 dogs over 27 days by rapid pacing (230 beats/min). Seven animals underwent sham surgery, and 8 animals received 3 transventricular Myosplint devices each.

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WebFeb 18, 2014 · In addition, a model of pacing-induced heart failure was employed to examine conditions of CHF and the results may be different in heart failure of a different origin. Conclusion. The present data demonstrate for the first time that a fast phase-III repolarization was associated with a low proarrhythmic potential in CHF, whereas a more … WebAug 21, 2010 · Second, we used a pacing-induced heart failure canine model [ 30] to observe the global and RWM abnormalities after long-term (2 months) rapid pacing …

WebDec 4, 2014 · In dogs with heart failure induced by 6 weeks of atrial tachy- pacing, PITA (starting on week 3) suppressed progressive cardiac … WebDec 1, 2010 · Canine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University …

WebThe aim of the study was to use the isolated blood-perfused rat heart to: (i) determine whether brief intermittent rapid pacing and ventricular fibrillation ar 掌桥科研一站式科研服务平台 WebJul 1, 2024 · The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during exercise in conscious dogs with pacing-induced heart failure. J Pharmacol …

WebMar 19, 1999 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling have not been investigated in this model.

WebMar 20, 2001 · The canine pacing-induced heart failure model shows a pattern of E-C coupling changes similar to that of humans: I Ca,L of normal amplitude triggers Ca i transients and contractions much smaller than normal, whereas SR Ca uptake is markedly impaired. 11 The present study investigates whether the defect in E-C coupling is due to … shula\\u0027s hotel and golfWebJan 31, 2024 · Heart failure (HF) has been proposed as a potential indication of renal denervation (RDN). However, the mechanisms enabling RDN to attenuate HF are not well understood, especially the central … shula\\u0027s houston txWebIn studies aimed at characterizing the canine pacing-induced heart failure model further, it was demonstrated that atrial ERP was unchanged prior to the initiation of AF (Li et al., 1999). The extent of atrial fibrosis, however, was increased dramatically (from 0.3% in control to ∼15% in animals in congestive heart failure), a structural ... the outback garden coWebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular … shula\u0027s health clubWeb20 hours ago · Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol. 1998; 30:1757–1762. doi: 10.1006/jmcc.1998.0739 Crossref Medline Google Scholar; 105. Marin-Garcia J, Goldenthal MJ, Moe GW. Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. … the outback exploratoriumWebJul 10, 2024 · The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = … shula\u0027s hotel and golf resortWebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated … the outbacker stove