Diabetes trials summary
WebKnown as the Diabetes Control and Complications Trial (DCCT), this landmark trial showed the superiority of intensive blood glucose management in controlling blood glucose and reducing the incidence of complications in type 1 diabetes. WebJun 9, 2024 · Duration of diabetes: 10.5 years Baseline hemoglobin A1c: 7.4% Metformin: 81.2%, insulin: 24% Principal Findings: The primary outcome, CV death, MI, or stroke for dulaglutide vs. placebo, was 12.0% vs. 13.4% (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.79-0.99; p = 0.026 for superiority)
Diabetes trials summary
Did you know?
WebDiabetes can lead to many complications, both macrovascular (heart attack and stroke) and microvascular (eye, kidney, and nerve damage). Below we summarize many of the … WebKnown as the Diabetes Control and Complications Trial (DCCT), this landmark trial showed the superiority of intensive blood glucose management in controlling blood glucose and …
WebDec 5, 2024 · DiRECT is a pragmatic trial done under real-life, primary care conditions in a sample of people with type 2 diabetes typical of those managed routinely in this setting. Relatively low-intensity training and support of existing staff, and appropriate resource redistribution, could facilitate provision of this intervention and dissemination of ... WebApr 29, 2024 · Results: This trial demonstrated that, in people with type 2 diabetes and cardiovascular markers (for example, protein in their urine), intensive treatment for …
WebNov 6, 2024 · For each included trial, summary data were extracted from the principal and relevant subsidiary peer-reviewed publications, independently and in duplicate by two authors (KJM, AJR) with discrepancies resolved by consensus discussion (appendix p 4). For trials without previously published relevant outcomes, results were provided by trial ... WebOct 2, 2024 · The goal of the trial was to assess the cardiovascular (CV) safety of albiglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, in patients with type 2 diabetes at high risk for CV events. Study Design Patients were randomized in a 1:1 fashion to either albiglutide once weekly (n = 4,731) or matching placebo (n = 4,732).
WebDiabetes can lead to many complications, both macrovascular (heart attack and stroke) and microvascular (eye, kidney, and nerve damage). Below we summarize many of the largest and most well-known trials which investigated prevention of these complications with a range of A1C targets.
WebGeneral Description. Short-term studies have shown numerous benefits of weight loss in overweight or obese patients, including improvements in glycemic control, risk factors for cardiovascular disease, quality of life, and other obesity-related coexisting illnesses. The Look AHEAD study was designed to test whether weight loss similarly ... imax theater dubaiWebNov 1, 2009 · It is noteworthy that the STENO-2 trial, which tested an aggressive strategy targeting glucose, BP, and lipids in high-risk individuals with type 2 … imax theater gainesville gaWebMar 31, 2024 · The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and … imax theater fremontWebNov 8, 2024 · Dapagliflozin vs. placebo was associated with a 2.3-point increase in KCCQ overall summary score from baseline to 8 months (p < 0.0001). Results according to diabetes status: Dapagliflozin/placebo HRs of the primary outcome according to diabetes: Diabetes: HR 0.75 (95% CI 0.63-0.90) No diabetes: HR 0.73 (95% CI 0.60-0.88) (p for … imax theater frisco txWebThe NIDDK funded the landmark Diabetes Control and Complications Trial (DCCT) to see if people with type 1 diabetes who kept their blood glucose levels as close to normal as safely possible with intensive diabetes treatment (three or more shots of insulin per day or an insulin pump with self-monitoring of blood glucose at least four times per … list of idaho zip codes by countyimax theater fort worthWebJan 1, 2002 · SUMMARY OF THE MAIN RESULTS AND CONCLUSIONS OF THE UKPDS The UKPDS results establish that retinopathy, nephropathy, and possibly neuropathy are benefited by lowering blood glucose levels in type 2 diabetes with intensive therapy, which achieved a median HbA 1c of 7.0% compared with conventional therapy with a median … imax theater gatlinburg tennessee