Myocredin
Myocardin is a protein that in humans is encoded by the MYOCD gene. Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM] Webmyocardin ( mĪ-ō-kahr'din ), A specific protein that is expressed in cardiac and smooth muscles cells. It has a role as a transcription factor and coactivates cardiac muscle …
Myocredin
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WebMyocardin: a component of a molecular switch for smooth muscle differentiation A hallmark of smooth muscle cells (SMCs) in culture and the injured vessel wall is their phenotypic … WebMyocardin (MYOCD) promotes Smad3-mediated transforming growth factor-β (TGF-β) signaling in mouse fibroblast cells. Our previous studies show that TGF-β/SMADs signaling activation enhances epithelial-mesenchymal transition (EMT) in human non-small cell lung cancer (NSCLC) cells. However, whether and …
Web1 day ago · RT @HaoYin20: #Myocardin is not only a transcriptional activator for #SmoothMuscleCell contractile genes but also ⏫splicing factors RBPMS/RBFOX2/MBNL1-> controls # ... WebSmooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes.
WebFeb 6, 2024 · Myocardin (MYOCD) was discovered to be a potent transcriptional coactivator of serum response factor (SRF) and required for the development and differentiation of cardiomyocyte and smooth muscle ... WebApr 15, 2024 · Cardiac diseases are the foremost cause of morbidity and mortality worldwide. The heart has limited regenerative potential; therefore, lost cardiac tissue cannot be replenished after cardiac injury. Conventional therapies are unable to restore functional cardiac tissue. In recent decades, much attention has been paid to regenerative medicine …
WebOct 23, 2002 · Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that associates with serum response factor (SRF) to potently enhance SRF-dependent … synopticityWebMar 1, 2024 · Targeting myocardin and MRTF-A by CCG-203971 leads to actin cytoskeleton-dependent inhibition of HSC activation, reduced cell contractility, impeded cell migration and proliferation, and decreased COL.1 expression in vitro and in vivo. Dual expression of myocardin and MRTF-A in HSCs may represent novel therapeutic targets in liver fibrosis. synoptic liftWebMay 1, 2008 · Background— Myocardin (Myocd) is a strong coactivator that binds the serum response factor (SRF) transcription factor over CArG elements embedded within smooth muscle cell (SMC) and cardiac muscle cyto-contractile genes. synopticism definitionWebOne such factor could be myocardin, a novel SRF coactivator recently cloned from cardiac tissue. Levels of myocardin are abundantly expressed in rat aortic media along with key SMC-restricted genes. In several SMC lines, myocardin mRNA levels decrease in parallel with the loss or attenuation of SMC marker expression. synoptic level 3WebOct 25, 2024 · Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell. 2001; 105:851–862. doi: 10.1016/s0092-8674(01)00404-4 Crossref Medline Google Scholar; 12. Wang Z, Wang DZ, Pipes GC, Olson EN. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad … thales glassdoorWebRequested access is restricted. Please login first with your OCU username and password. thales germany addressWebMyocardin (MYOCD) the most important coactivator of serum response factor (SRF), plays a critical role specifically in the development of cardiac myocytes and vascular smooth muscle cells (VSMCs). Binding of Myocardin to the SRF on the CArG box-containing target genes can transcriptionally activate … Myocardin: A novel player in atherosclerosis synoptic journal template