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Tph2-creer

SpletDescription. This AAV expresses Cre driven by an Tryptophan hydroxylase promoter TPH2 promoter; is available in AAV1; AAV2; AAV5; AAV6; AAV8; AAV9; AAV.rh10; AAV.DJ; … Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003, serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in periphe…

Generation and characterization of Tph2-/- mice. (A) Top: …

Splet19. mar. 2024 · 这种新型Cre重组酶结合了诱导型CreER和持续活化的Cre重组酶的优点，既提高了重组效率又具有时间可控性，弥补了传统CreER和Cre重组酶介导的遗传操作技术 … SpletDuke大学医学中心的分子生物学教授James B. Duke等又在动物试验中观察到，一种名为色氨酸羟化酶-2 (TPH2)的特殊蛋白会影响小白鼠脑组织中的 5-羟色胺 正常含量，而后者 … cycling news free https://ltmusicmgmt.com

An adult-stage transcriptional program for survival of serotonergic ...

SpletC57BL/6J (8-12 weeks, 20-25g, stock 000664), Tph2-CreER (stock 016584), nNos-/-(stock 002986), and SERT-Cre (stock 014554) mice were purchased from the Jackson … Splet03. sep. 2015 · To this end, floxed CB 1 receptor mice (Marsicano et al., 2003) were crossed with a transgenic mouse line expressing the tamoxifen-inducible Cre recombinase under … Splet01. mar. 2011 · As illustrated in Figure 7, ISH was successfully used to detect Cre mRNA in the raphe nuclei of the Tph2-CreER T2 mice (Fig. 7A). Cre expression was similar to lacZ … cyclingnews flat finder

JCI - Estrogens stimulate serotonin neurons to inhibit binge-like ...

Category:loxP转基因动物的构建 - 实验方法 - 丁香通 - biomart.cn

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Tph2-creer

小鼠研究院丨层层解析条件性基因敲除的“时空开关”—— Cre-loxP系 …

Splet21. jul. 2024 · TPH2-CreER mice (12 weeks of age) were anesthetized with isoflurane and received stereotaxic injections of Cre-dependent AAV expressing ChR2-YFP (AAV-EF1α … http://muchong.com/html/201411/8111483.html

Tph2-creer

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SpletRESULTS To investigate adult-stage Lmx1b and Pet1 functions, we developed a tamoxifen (TAM)-inducible strategy with the Tph2-CreER transgenic line to target Pet1 (iPKO: Pet1fl/fl; Tph2-CreER; Ai9), or Lmx1b (iLKO: Lmx1bfl/fl; Tph2-CreER; Ai9),orboth(iDKO:Pet1fl/fl/Lmx1b ;Tph2-CreER;Ai9)inadult 5-HT neurons while … SpletTg (Tph2-cre/ERT2)1.38Zi Transgene Detail MGI Mouse (MGI:4830865) Search All Search Tools Genes Genes & Markers Query Batch Query JBrowse Genome Browser Multiple …

Splet21. feb. 2024 · 一、品系介绍：Cre-ERT2小鼠是一类含有雌激素受体（estrogen receptor，ER）的配体结合区突变体（ERT）与Cre重组酶的融合蛋白表达的小鼠。Cre … Splet20. avg. 2024 · Cre重组酶（Cyclization Recombination Enzyme）由大肠杆菌噬菌体P1的Cre基因编码，是由343个氨基酸组成的38kD的蛋白质。它不仅具有催化活性，而且与限 …

SpletThese TPH2-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Tph2 promoter and may be useful for generating conditional … Splet26. avg. 2014 · This cross produced Tph2-CreER Rosa26-tdTOMATO (WT) and Esr1 fl/fl Tph2-CreER Rosa26-tdTOMATO (KO) mice. Upon tamoxifen inductions similar to those …

SpletTph2-CreER. mouse line in which expression of tamoxifen-inducible Cre recombinase is driven by tryptophan hydroxylase 2 (Tph2) promoter. To this end, Tph2-CreER. mice were …

Splet16. jun. 2024 · Tph2 是中枢合成5-HT 的一个酶， 敲除这个基因之后，中枢的 5-HT 显著缺失，制造的基因小鼠，是研究5-HT功能的一个最新工具模型。 Tph2敲除 严重影响了嗅觉 … cyclingnews autobusSplet答案解析. 查看更多优质解析. 解答一. 举报. Fig.S (后加数字)是说supplement里的图片. 一般一篇文献后面还有supplement materials,交代更详细的一些情况. 解析看不懂？. 免费查看 … cheap yorkies for sale in marylandSplet29. jul. 2024 · As with the Pet1-Cre driver, the Tph2-CreER activated TdTomato + cells that are Tph2-evidently express Tph2 at a low level (Deneris and Gaspar, 2024; Okaty et al., … cheap yorkies for adoptionSpletRosa26-LSL-tdTOMATO, AgRP-Cre/Rosa26-LSL-tdTOMATO, or DAT-CreER/ Rosa26-LSL-tdTOMATO mice to generate compound Cre lines for CRACM studies, as described … cycling news headlinesSpletCreERT由三个关键字Cre、ER、T组合而成，分别对应于 CreERT 系统中的三个关键物质： Cre 重组酶、雌激素受体（ ER ，estrogen receptor）和药物他莫昔芬（ T ，Tamoxifen） … cycling news cyclocrosshttp://knockout.cwru.edu/publications/Kitt.pdf cycling news israeli start up nation twitterSplet23. maj 2011 · Deletion of the leptin receptor from serotonergic neurons in six-week-old mice using the Tph2–CreER T2 mice resulted in a massive increase of appetite and a … cycling news fairlight